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Structure paper

TitleKlebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Journal, issue, pagesNat. Chem. Biol., Vol. 13, Page 1129-1136, Year 2017
Publish dateJun 12, 2017 (structure data deposition date)
AuthorsMetelev, M. / Osterman, I.A. / Ghilarov, D. / Khabibullina, N.F. / Yakimov, A. / Shabalin, K. / Utkina, I. / Travin, D.Y. / Komarova, E.S. / Serebryakova, M. ...Metelev, M. / Osterman, I.A. / Ghilarov, D. / Khabibullina, N.F. / Yakimov, A. / Shabalin, K. / Utkina, I. / Travin, D.Y. / Komarova, E.S. / Serebryakova, M. / Artamonova, T. / Khodorkovskii, M. / Konevega, A.L. / Sergiev, P.V. / Severinov, K. / Polikanov, Y.S.
External linksNat. Chem. Biol. / PubMed:28846667
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-5w4k:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (bacteria)
  • thermus thermophilus hb8 (bacteria)
  • enterobacteria phage t4 (virus)
  • klebsiella pneumoniae subsp. ozaenae (bacteria)
Keywordsribosome/antibiotic / Klebsazolicin / antibiotic / RiPPs / ribosome inhibitor / 70S ribosome / inhibition of translation / peptidyl transferase center / nascent peptide exit tunnel / ribosome-antibiotic complex

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