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TitleImproving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.
Journal, issue, pagesCell Rep, Vol. 20, Page 1805-1817, Year 2017
Publish dateJul 6, 2017 (structure data deposition date)
AuthorsTorrents de la Pena, A. / Julien, J.P. / de Taeye, S.W. / Garces, F. / Guttman, M. / Ozorowski, G. / Pritchard, L.K. / Behrens, A.J. / Go, E.P. / Burger, J.A. ...Torrents de la Pena, A. / Julien, J.P. / de Taeye, S.W. / Garces, F. / Guttman, M. / Ozorowski, G. / Pritchard, L.K. / Behrens, A.J. / Go, E.P. / Burger, J.A. / Schermer, E.E. / Sliepen, K. / Ketas, T.J. / Pugach, P. / Yasmeen, A. / Cottrell, C.A. / Torres, J.L. / Vavourakis, C.D. / van Gils, M.J. / LaBranche, C. / Montefiori, D.C. / Desaire, H. / Crispin, M. / Klasse, P.J. / Lee, K.K. / Moore, J.P. / Ward, A.B. / Wilson, I.A. / Sanders, R.W.
External linksCell Rep / PubMed:28834745
MethodsX-ray diffraction
Resolution7 Å
Structure data

PDB-5wdu:
HIV-1 Env BG505 SOSIP.664 H72C-H564C trimer in complex with bNAbs PGT122 Fab, 35O22 Fab and NIH45-46 scFv
Method: X-RAY DIFFRACTION / Resolution: 7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HIV-1 Env / broadly neutralizing antibodies / viral glycoprotein

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