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Title | Design, Synthesis, and Biological Evaluation of Novel Type I(1)/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 8027-8054, Year 2017 |
Publish date | Jan 11, 2017 (structure data deposition date) |
Authors | Walter, N.M. / Wentsch, H.K. / Buhrmann, M. / Bauer, S.M. / Doring, E. / Mayer-Wrangowski, S. / Sievers-Engler, A. / Willemsen-Seegers, N. / Zaman, G. / Buijsman, R. ...Walter, N.M. / Wentsch, H.K. / Buhrmann, M. / Bauer, S.M. / Doring, E. / Mayer-Wrangowski, S. / Sievers-Engler, A. / Willemsen-Seegers, N. / Zaman, G. / Buijsman, R. / Lammerhofer, M. / Rauh, D. / Laufer, S.A. |
External links | J. Med. Chem. / PubMed:28834431 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.31 Å |
Structure data | PDB-5mtx: PDB-5mty: |
Chemicals | ChemComp-FJI: ChemComp-BOG: ChemComp-HOH: ChemComp-HB9: |
Source |
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Keywords | TRANSFERASE / kinase / inhibitor / p38 / complex / type 1.5 |