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Structure paper

TitleTwo-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 angstrom crystal structure of the complex.
Journal, issue, pagesMAbs, Vol. 9, Page 1088-1104, Year 2017
Publish dateMay 24, 2016 (structure data deposition date)
AuthorsLobner, E. / Humm, A.S. / Mlynek, G. / Kubinger, K. / Kitzmuller, M. / Traxlmayr, M.W. / Djinovic-Carugo, K. / Obinger, C.
External linksMAbs / PubMed:28816592
MethodsX-ray diffraction
Resolution2.15 - 2.5 Å
Structure data

PDB-5k64:
Crystal structure of VEGF binding IgG1-Fc (Fcab 448)
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

PDB-5k65:
Crystal structure of VEGF binding IgG1-Fc (Fcab CT6)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5o4e:
Crystal structure of VEGF in complex with heterodimeric Fcab JanusCT6
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-CAC:
CACODYLATE ION

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody engineering / immunoglobulin G1 / Fc fragment / glycosylations / CH3 domain / Fcab / VEGF / vascular endothelial growth factor / heterodimeric Fcab

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