タイトル | Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. U.S.A., Year 2017 |
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掲載日 | 2015年8月26日 (構造データの登録日) |
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著者 | Lind, G.E. / Mou, T.C. / Tamborini, L. / Pomper, M.G. / De Micheli, C. / Conti, P. / Pinto, A. / Hansen, K.B. |
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リンク | Proc. Natl. Acad. Sci. U.S.A. / PubMed:28760974 |
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手法 | X線回折 |
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解像度 | 1.951 - 2.4 Å |
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構造データ | PDB-5dex: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5vih: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-fluorophenyl-ACEPC 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5vii: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-(3-fluoropropyl)phenyl-ACEPC 手法: X-RAY DIFFRACTION / 解像度: 1.951 Å PDB-5vij: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-bromophenyl-ACEPC 手法: X-RAY DIFFRACTION / 解像度: 2.105 Å |
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化合物 | ChemComp-5E0: 5-[(2R)-2-amino-2-carboxyethyl]-1-phenyl-1H-pyrazole-3-carboxylic acid
ChemComp-5DZ: 5-[(2R)-2-amino-2-carboxyethyl]-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid
ChemComp-5DY: 5-[(2R)-2-amino-2-carboxyethyl]-1-[4-(3-fluoropropyl)phenyl]-1H-pyrazole-3-carboxylic acid
ChemComp-5DX: 5-[(2R)-2-amino-2-carboxyethyl]-1-(4-bromophenyl)-1H-pyrazole-3-carboxylic acid
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由来 | ![](img/tx_mammal.gif) rattus norvegicus (ドブネズミ)
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キーワード | TRANSPORT PROTEIN / RECEPTOR / NMDA receptor / Antagonist |
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