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TitleDiscovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.
Journal, issue, pagesJ. Med. Chem., Vol. 60, Page 7658-7676, Year 2017
Publish dateMay 8, 2017 (structure data deposition date)
AuthorsMikami, S. / Sasaki, S. / Asano, Y. / Ujikawa, O. / Fukumoto, S. / Nakashima, K. / Oki, H. / Kamiguchi, N. / Imada, H. / Iwashita, H. / Taniguchi, T.
External linksJ. Med. Chem. / PubMed:28759228
MethodsX-ray diffraction
Resolution2.16 Å
Structure data

PDB-5xkm:
Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-87R:
6-methyl-N-[(1R)-1-[4-(trifluoromethyloxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Hydrolase Inhibitor / PDE2A

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