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TitleFunctional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.
Journal, issue, pagesMAbs, Vol. 9, Page 1129-1142, Year 2017
Publish dateApr 27, 2017 (structure data deposition date)
AuthorsZhang, D. / Armstrong, A.A. / Tam, S.H. / McCarthy, S.G. / Luo, J. / Gilliland, G.L. / Chiu, M.L.
External linksMAbs / PubMed:28758875
MethodsX-ray diffraction
Resolution3.1 Å
Structure data

PDB-5vme:
Crystal structure of human IgG1 Fc K248E, T437R mutant
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fc / Immunoglobulin Fold

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