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TitleDevelopment of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.
Journal, issue, pagesChemMedChem, Vol. 12, Page 1436-1448, Year 2017
Publish dateJun 6, 2017 (structure data deposition date)
AuthorsMcComas, C.C. / Palani, A. / Chang, W. / Holloway, M.K. / Lesburg, C.A. / Li, P. / Liverton, N. / Meinke, P.T. / Olsen, D.B. / Peng, X. ...McComas, C.C. / Palani, A. / Chang, W. / Holloway, M.K. / Lesburg, C.A. / Li, P. / Liverton, N. / Meinke, P.T. / Olsen, D.B. / Peng, X. / Soll, R.M. / Ummat, A. / Wu, J. / Zorn, N. / Ludmerer, S.W.
External linksChemMedChem / PubMed:28741898
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-5w2e:
HCV NS5B RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor MK-8876
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-9VY:
2-(4-fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide

ChemComp-HOH:
WATER

Source
  • hepatitis c virus genotype 1b (isolate bk)
KeywordsTRANSFERASE/INHIBITOR / antiviral inhibitor / HCV / polymerase / VIRAL PROTEIN / TRANSFERASE-INHIBITOR complex

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