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Structure paper

TitleAn engineered protein antagonist of K-Ras/B-Raf interaction.
Journal, issue, pagesSci Rep, Vol. 7, Page 5831-5831, Year 2017
Publish dateJan 4, 2017 (structure data deposition date)
AuthorsKauke, M.J. / Traxlmayr, M.W. / Parker, J.A. / Kiefer, J.D. / Knihtila, R. / McGee, J. / Verdine, G. / Mattos, C. / Wittrup, K.D.
External linksSci Rep / PubMed:28724936
MethodsX-ray diffraction
Resolution2.199 - 2.302 Å
Structure data

PDB-5ufe:
Wild-type K-Ras(GNP)/R11.1.6 complex
Method: X-RAY DIFFRACTION / Resolution: 2.302 Å

PDB-5ufq:
K-RasG12D(GNP)/R11.1.6 complex
Method: X-RAY DIFFRACTION / Resolution: 2.199 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-CA:
Unknown entry

ChemComp-CD:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-CO:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • sulfolobus solfataricus (archaea)
KeywordsHydrolase/DE NOVO PROTEIN / Ras / GTPase / inhibitor / binder / Hydrolase-DE NOVO PROTEIN complex / complex

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