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TitleModulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Journal, issue, pagesNat Commun, Vol. 8, Page 16066-16066, Year 2017
Publish dateSep 12, 2016 (structure data deposition date)
AuthorsChen, L. / Aleshin, A.E. / Alitongbieke, G. / Zhou, Y. / Zhang, X. / Ye, X. / Hu, M. / Ren, G. / Chen, Z. / Ma, Y. ...Chen, L. / Aleshin, A.E. / Alitongbieke, G. / Zhou, Y. / Zhang, X. / Ye, X. / Hu, M. / Ren, G. / Chen, Z. / Ma, Y. / Zhang, D. / Liu, S. / Gao, W. / Cai, L. / Wu, L. / Zeng, Z. / Jiang, F. / Liu, J. / Zhou, H. / Cadwell, G. / Liddington, R.C. / Su, Y. / Zhang, X.K.
External linksNat Commun / PubMed:28714476
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-5tbp:
Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-7A4:
[(1Z)-5-fluoro-2-methyl-1-{[4-(propan-2-yl)phenyl]methylidene}-1H-inden-3-yl]acetic acid

ChemComp-ACT:
ACETATE ION

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / nuclear receptor / Sulindac / AKT activation / Complex / tetramer / RXR / LBD

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