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Structure paper

TitleStructural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Journal, issue, pagesNat Commun, Vol. 8, Page 16111-16111, Year 2017
Publish dateMay 22, 2017 (structure data deposition date)
AuthorsGuillard, S. / Kolasinska-Zwierz, P. / Debreczeni, J. / Breed, J. / Zhang, J. / Bery, N. / Marwood, R. / Tart, J. / Overman, R. / Stocki, P. ...Guillard, S. / Kolasinska-Zwierz, P. / Debreczeni, J. / Breed, J. / Zhang, J. / Bery, N. / Marwood, R. / Tart, J. / Overman, R. / Stocki, P. / Mistry, B. / Phillips, C. / Rabbitts, T. / Jackson, R. / Minter, R.
External linksNat Commun / PubMed:28706291
MethodsX-ray diffraction
Resolution2.19 - 3.22 Å
Structure data

PDB-5o2s:
Human KRAS in complex with darpin K27
Method: X-RAY DIFFRACTION / Resolution: 3.22 Å

PDB-5o2t:
Human KRAS in complex with darpin K27
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

Chemicals

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / KRAS / RAS signalling / darpin / nucleotide exchange

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