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Title | Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 6942-6990, Year 2017 |
Publish date | Feb 17, 2017 (structure data deposition date) |
![]() | Okawa, T. / Aramaki, Y. / Yamamoto, M. / Kobayashi, T. / Fukumoto, S. / Toyoda, Y. / Henta, T. / Hata, A. / Ikeda, S. / Kaneko, M. ...Okawa, T. / Aramaki, Y. / Yamamoto, M. / Kobayashi, T. / Fukumoto, S. / Toyoda, Y. / Henta, T. / Hata, A. / Ikeda, S. / Kaneko, M. / Hoffman, I.D. / Sang, B.C. / Zou, H. / Kawamoto, T. |
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Methods | X-ray diffraction |
Resolution | 2.65 - 2.7 Å |
Structure data | ![]() PDB-5uuu: ![]() PDB-5uvc: |
Chemicals | ![]() ChemComp-QRW: ![]() ChemComp-SO4: ![]() ChemComp-MES: ![]() ChemComp-HOH: ![]() ChemComp-8PV: |
Source |
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![]() | Transferase/Transferase Inhibitor / Kinase / Inhibitor / Heart Failure / Transferase-Transferase Inhibitor complex |