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-Structure paper
Title | A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 13, Page 943-950, Year 2017 |
Publish date | Sep 15, 2016 (structure data deposition date) |
![]() | Wellington, S. / Nag, P.P. / Michalska, K. / Johnston, S.E. / Jedrzejczak, R.P. / Kaushik, V.K. / Clatworthy, A.E. / Siddiqi, N. / McCarren, P. / Bajrami, B. ...Wellington, S. / Nag, P.P. / Michalska, K. / Johnston, S.E. / Jedrzejczak, R.P. / Kaushik, V.K. / Clatworthy, A.E. / Siddiqi, N. / McCarren, P. / Bajrami, B. / Maltseva, N.I. / Combs, S. / Fisher, S.L. / Joachimiak, A. / Schreiber, S.L. / Hung, D.T. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.35 - 2.46 Å |
Structure data | ![]() PDB-5tcf: ![]() PDB-5tcg: ![]() PDB-5tch: ![]() PDB-5tci: ![]() PDB-5tcj: |
Chemicals | ![]() ChemComp-MLI: ![]() ChemComp-FMT: ![]() ChemComp-K: ![]() ChemComp-HOH: ![]() ChemComp-P1T: ![]() ChemComp-CS: ![]() ChemComp-79V: |
Source |
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![]() | LYASE / PLP / heterotetramer / amino acid biosynthesis / substrate channeling / allostery / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID |