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TitleEngineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.
Journal, issue, pagesBiochem. J., Vol. 474, Page 2601-2617, Year 2017
Publish dateSep 21, 2016 (structure data deposition date)
AuthorsZur, Y. / Rosenfeld, L. / Bakhman, A. / Ilic, S. / Hayun, H. / Shahar, A. / Akabayov, B. / Kosloff, M. / Levaot, N. / Papo, N.
External linksBiochem. J. / PubMed:28655719
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-5lxf:
Crystal structure of the human Macrophage Colony Stimulating Factor M- CSF_C31S variant
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Drug design / rational protein engineering / receptor tyrosine kinase / osteoporosis

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