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TitleThe Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
Journal, issue, pagesBiochemistry, Vol. 56, Page 3443-3453, Year 2017
Publish dateNov 11, 2016 (structure data deposition date)
AuthorsPatel, M.P. / Hu, L. / Stojanoski, V. / Sankaran, B. / Prasad, B.V.V. / Palzkill, T.
External linksBiochemistry / PubMed:28613873
MethodsX-ray diffraction
Resolution1.4 - 2.2 Å
Structure data

PDB-5tw6:
CTX-M-14 P167S:E166A mutant with acylated ceftazidime molecule
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5twd:
CTX-M-14 P167S apoenzyme
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5twe:
CTX-M-14 P167S:S70G mutant enzyme crystallized with ceftazidime
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-5u53:
CTX-M-14 E166A with acylated ceftazidime molecule
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-5vth:
CTX-M-14 P167S:E166A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CAZ:
ACYLATED CEFTAZIDIME

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-NO3:
NITRATE ION

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE/ANTIBIOTIC / CTX-M beta-lactamase ceftazidime acyl-enzyme complex / HYDROLASE-ANTIBIOTIC complex / HYDROLASE / CTX-M beta-lactamase apoenzyme / CTX-M beta-lactamase ceftazidime / CTX-M beta-lactamase / ceftazidime acyl-enzyme complex

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