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TitleStructural studies of viperin, an antiviral radical SAM enzyme.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 6806-6811, Year 2017
Publish dateMay 11, 2017 (structure data deposition date)
AuthorsFenwick, M.K. / Li, Y. / Cresswell, P. / Modis, Y. / Ealick, S.E.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28607080
MethodsX-ray diffraction
Resolution1.7 - 1.972 Å
Structure data

PDB-5vsl:
Crystal structure of viperin with bound [4Fe-4S] cluster and S-adenosylhomocysteine (SAH)
Method: X-RAY DIFFRACTION / Resolution: 1.972 Å

PDB-5vsm:
Crystal structure of viperin with bound [4Fe-4S] cluster, 5'-deoxyadenosine, and L-methionine
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

ChemComp-5AD:
5'-DEOXYADENOSINE

ChemComp-MET:
METHIONINE

Source
  • mus musculus (house mouse)
KeywordsANTIVIRAL PROTEIN / radical / S-adenosylmethionine / iron-sulfur cluster / antiviral response

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