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TitleFunctional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 12632-12642, Year 2017
Publish dateMar 22, 2017 (structure data deposition date)
AuthorsPirone, L. / Ripoll-Rozada, J. / Leone, M. / Ronca, R. / Lombardo, F. / Fiorentino, G. / Andersen, J.F. / Pereira, P.J.B. / Arca, B. / Pedone, E.
External linksJ. Biol. Chem. / PubMed:28592490
MethodsX-ray diffraction
Resolution1.45 Å
Structure data

PDB-5nhu:
HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • anopheles gambiae (African malaria mosquito)
  • homo sapiens (human)
KeywordsHYDROLASE / blood clotting / anticoagulant / thrombin / inhibitor

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