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TitleTethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Journal, issue, pagesNucleic Acids Res., Vol. 45, Page 8596-8608, Year 2017
Publish dateMar 24, 2017 (structure data deposition date)
AuthorsWeikum, E.R. / de Vera, I.M.S. / Nwachukwu, J.C. / Hudson, W.H. / Nettles, K.W. / Kojetin, D.J. / Ortlund, E.A.
External linksNucleic Acids Res. / PubMed:28591827
MethodsX-ray diffraction
Resolution2.153 - 2.295 Å
Structure data

PDB-5va0:
Glucocorticoid Receptor DNA Binding Domain in complex with AP-1 response element from VCAM-1 Promoter
Method: X-RAY DIFFRACTION / Resolution: 2.295 Å

PDB-5va7:
Glucocorticoid Receptor DNA Binding Domain - IL11 AP-1 recognition element Complex
Method: X-RAY DIFFRACTION / Resolution: 2.153 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstranscription/dna / Nuclear Receptor / Transcription Factor / DNA Binding / Development / Protein-DNA complex / transcription-dna complex

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