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Structure paper

TitleHigh-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Journal, issue, pagesGlycobiology, Vol. 27, Page 966-977, Year 2017
Publish dateOct 4, 2016 (structure data deposition date)
AuthorsGagnon, S.M.L. / Legg, M.S.G. / Sindhuwinata, N. / Letts, J.A. / Johal, A.R. / Schuman, B. / Borisova, S.N. / Palcic, M.M. / Peters, T. / Evans, S.V.
External linksGlycobiology / PubMed:28575295
MethodsX-ray diffraction
Resolution1.45 - 1.89 Å
Structure data

PDB-5tjk:
Crystal structure of GTA + A trisaccharide (native)
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-5tjl:
Crystal structure of GTA + A trisaccharide (mercury derivative)
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-5tjn:
Crystal structure of GTB + B trisaccharide (native)
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

PDB-5tjo:
Crystal structure of GTB + B trisaccharide (mercury derivative)
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-HG:
Unknown entry

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / glycosyltransferases / histo blood group enzymes / product trisaccharide / GT-A fold

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