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TitleCryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 11829-11839, Year 2017
Publish dateMar 9, 2017 (structure data deposition date)
AuthorsChitty, J.L. / Blake, K.L. / Blundell, R.D. / Koh, Y.Q.A.E. / Thompson, M. / Robertson, A.A.B. / Butler, M.S. / Cooper, M.A. / Kappler, U. / Williams, S.J. ...Chitty, J.L. / Blake, K.L. / Blundell, R.D. / Koh, Y.Q.A.E. / Thompson, M. / Robertson, A.A.B. / Butler, M.S. / Cooper, M.A. / Kappler, U. / Williams, S.J. / Kobe, B. / Fraser, J.A.
External linksJ. Biol. Chem. / PubMed:28559277
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-5v4l:
Cryptococcus neoformans adenylosuccinate lyase
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • cryptococcus neoformans (Cryptococcus neoformans serotype A)
KeywordsLYASE / fumerase / adenylosuccinate / SAICAR

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