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TitleAgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 56, Page 8672-8676, Year 2017
Publish dateMay 1, 2017 (structure data deposition date)
AuthorsLiu, Y. / Fares, M. / Dunham, N.P. / Gao, Z. / Miao, K. / Jiang, X. / Bollinger, S.S. / Boal, A.K. / Zhang, X.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:28557281
MethodsX-ray diffraction
Resolution2.23 Å
Structure data

PDB-5vnp:
X-ray crystal structure of Halotag bound to the P1 benzoxadiazole fluorogenic ligand
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

Chemicals

ChemComp-9FM:
N-{2-[2-(hexyloxy)ethoxy]ethyl}-N~2~-methyl-N~2~-{[7-(methylamino)-2,1,3-benzoxadiazol-4-yl]sulfonyl}glycinamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rhodococcus rhodochrous (bacteria)
KeywordsHYDROLASE / biosensor / cytotoxicity / fluorescent probe / protein aggregation / proteome stress

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