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TitleWnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
Journal, issue, pagesGenes Dev., Vol. 31, Page 916-926, Year 2017
Publish dateFeb 21, 2017 (structure data deposition date)
AuthorsDeBruine, Z.J. / Ke, J. / Harikumar, K.G. / Gu, X. / Borowsky, P. / Williams, B.O. / Xu, W. / Miller, L.J. / Xu, H.E. / Melcher, K.
External linksGenes Dev. / PubMed:28546512
MethodsX-ray diffraction
Resolution2.56 Å
Structure data

PDB-5uwg:
The crystal structure of Fz4-CRD in complex with palmitoleic acid
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

Chemicals

ChemComp-PAM:
PALMITOLEIC ACID

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Wnt / Frizzled / signalosome / cysteine-rich domain / Wnt5a / Wnt8 / Frizzled-4

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