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-Structure paper
Title | Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 3101-3106, Year 2017 |
Publish date | May 2, 2017 (structure data deposition date) |
Authors | Hynes, J. / Wu, H. / Kempson, J. / Duan, J.J. / Lu, Z. / Jiang, B. / Stachura, S. / Tokarski, J.S. / Sack, J.S. / Khan, J.A. ...Hynes, J. / Wu, H. / Kempson, J. / Duan, J.J. / Lu, Z. / Jiang, B. / Stachura, S. / Tokarski, J.S. / Sack, J.S. / Khan, J.A. / Lippy, J.S. / Zhang, R.F. / Pitt, S. / Shen, G. / Gillooly, K. / McIntyre, K. / Carter, P.H. / Barrish, J.C. / Nadler, S.G. / Salter-Cid, L.M. / Fura, A. / Schieven, G.L. / Pitts, W.J. / Wrobleski, S.T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:28539220 |
Methods | X-ray diffraction |
Resolution | 2.65 Å |
Structure data | PDB-5vo6: |
Chemicals | ChemComp-9J4: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / TRANSFERASE / TRANSFERASE-INHIBITOR COMPLEX |