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-Structure paper
| Title | Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 2721-2726, Year 2017 |
| Publish date | Aug 22, 2016 (structure data deposition date) |
 Authors | Smith, G.F. / Altman, M.D. / Andresen, B. / Baker, J. / Brubaker, J.D. / Chen, H. / Chen, Y. / Childers, M. / Donofrio, A. / Ferguson, H. ...Smith, G.F. / Altman, M.D. / Andresen, B. / Baker, J. / Brubaker, J.D. / Chen, H. / Chen, Y. / Childers, M. / Donofrio, A. / Ferguson, H. / Fischer, C. / Fischmann, T.O. / Gibeau, C. / Hicks, A. / Jin, S. / Kattar, S. / Kleinschek, M.A. / Leccese, E. / Lesburg, C. / Li, C. / Lim, J. / Liu, D. / Maclean, J.K.F. / Mansoor, F. / Moy, L.Y. / Mulrooney, E.F. / Necheva, A.S. / Presland, J. / Rakhilina, L. / Yang, R. / Torres, L. / Zhang-Hoover, J. / Northrup, A. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:28501511 |
| Methods | X-ray diffraction |
| Resolution | 2.3 - 2.34 Å |
| Structure data |  PDB-5t1s:  PDB-5t1t: |
| Chemicals |  ChemComp-76Q:  ChemComp-HOH:  ChemComp-76P: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / INASE / PHOSPHATASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |
homo sapiens (human)