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TitleX-ray crystal structure of rivoglitazone bound to PPAR gamma and PPAR subtype selectivity of TZDs.
Journal, issue, pagesBiochim. Biophys. Acta, Vol. 1861, Page 1981-1991, Year 2017
Publish dateDec 6, 2016 (structure data deposition date)
AuthorsRajapaksha, H. / Bhatia, H. / Wegener, K. / Petrovsky, N. / Bruning, J.B.
External linksBiochim. Biophys. Acta / PubMed:28499821
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-5u5l:
X-ray Crystal Structure of the PPARgamma Ligand Binding Domain in Complex with Rivoglitazone
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-7VA:
(5S)-5-({4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/INHIBITOR / Nuclear Receptor / Peroxisome Proliferator Activated Receptor / rivoglitazone / TZD / TRANSCRIPTION-INHIBITOR complex

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