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TitleStructural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page E4223-E4232, Year 2017
Publish dateOct 27, 2016 (structure data deposition date)
AuthorsRamagopal, U.A. / Liu, W. / Garrett-Thomson, S.C. / Bonanno, J.B. / Yan, Q. / Srinivasan, M. / Wong, S.C. / Bell, A. / Mankikar, S. / Rangan, V.S. ...Ramagopal, U.A. / Liu, W. / Garrett-Thomson, S.C. / Bonanno, J.B. / Yan, Q. / Srinivasan, M. / Wong, S.C. / Bell, A. / Mankikar, S. / Rangan, V.S. / Deshpande, S. / Korman, A.J. / Almo, S.C.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28484017
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-5tru:
Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody / complex / Fab

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