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TitleLong lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Journal, issue, pagesSci Rep, Vol. 7, Page 1080-1080, Year 2017
Publish dateJun 3, 2016 (structure data deposition date)
AuthorsFukuzawa, T. / Sampei, Z. / Haraya, K. / Ruike, Y. / Shida-Kawazoe, M. / Shimizu, Y. / Gan, S.W. / Irie, M. / Tsuboi, Y. / Tai, H. ...Fukuzawa, T. / Sampei, Z. / Haraya, K. / Ruike, Y. / Shida-Kawazoe, M. / Shimizu, Y. / Gan, S.W. / Irie, M. / Tsuboi, Y. / Tai, H. / Sakiyama, T. / Sakamoto, A. / Ishii, S. / Maeda, A. / Iwayanagi, Y. / Shibahara, N. / Shibuya, M. / Nakamura, G. / Nambu, T. / Hayasaka, A. / Mimoto, F. / Okura, Y. / Hori, Y. / Habu, K. / Wada, M. / Miura, T. / Tachibana, T. / Honda, K. / Tsunoda, H. / Kitazawa, T. / Kawabe, Y. / Igawa, T. / Hattori, K. / Nezu, J.
External linksSci Rep / PubMed:28439081
MethodsX-ray diffraction
Resolution2.11 Å
Structure data

PDB-5b71:
Crystal structure of complement C5 in complex with SKY59
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / pH-dependent / recycling antibody / complement C5 / Fab / Complex

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