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TitleA Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 535-542, Year 2018
Publish dateMar 7, 2017 (structure data deposition date)
AuthorsMatyskiela, M.E. / Zhang, W. / Man, H.W. / Muller, G. / Khambatta, G. / Baculi, F. / Hickman, M. / LeBrun, L. / Pagarigan, B. / Carmel, G. ...Matyskiela, M.E. / Zhang, W. / Man, H.W. / Muller, G. / Khambatta, G. / Baculi, F. / Hickman, M. / LeBrun, L. / Pagarigan, B. / Carmel, G. / Lu, C.C. / Lu, G. / Riley, M. / Satoh, Y. / Schafer, P. / Daniel, T.O. / Carmichael, J. / Cathers, B.E. / Chamberlain, P.P.
External linksJ. Med. Chem. / PubMed:28425720
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-5v3o:
Cereblon in complex with DDB1 and CC-220
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-8W7:
(3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / E3 / ubiquitin ligase / CRL4 / DCAF

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