+Search query
-Structure paper
Title | Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 60, Page 3580-3590, Year 2017 |
Publish date | Nov 25, 2016 (structure data deposition date) |
Authors | Desroy, N. / Housseman, C. / Bock, X. / Joncour, A. / Bienvenu, N. / Cherel, L. / Labeguere, V. / Rondet, E. / Peixoto, C. / Grassot, J.M. ...Desroy, N. / Housseman, C. / Bock, X. / Joncour, A. / Bienvenu, N. / Cherel, L. / Labeguere, V. / Rondet, E. / Peixoto, C. / Grassot, J.M. / Picolet, O. / Annoot, D. / Triballeau, N. / Monjardet, A. / Wakselman, E. / Roncoroni, V. / Le Tallec, S. / Blanque, R. / Cottereaux, C. / Vandervoort, N. / Christophe, T. / Mollat, P. / Lamers, M. / Auberval, M. / Hrvacic, B. / Ralic, J. / Oste, L. / van der Aar, E. / Brys, R. / Heckmann, B. |
External links | J. Med. Chem. / PubMed:28414242 |
Methods | X-ray diffraction |
Resolution | 2.43 Å |
Structure data | PDB-5mhp: |
Chemicals | ChemComp-NAG: ChemComp-ZN: ChemComp-CA: ChemComp-MG: ChemComp-IOD: ChemComp-CL: ChemComp-SCN: ChemComp-PO4: ChemComp-7NB: ChemComp-HOH: |
Source |
|
Keywords | HYDROLASE / ATX / Inhibitor / ENPP2 |