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-Structure paper
Title | Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 3472-3483, Year 2017 |
Publish date | Feb 1, 2017 (structure data deposition date) |
Authors | Dyck, B. / Branstetter, B. / Gharbaoui, T. / Hudson, A.R. / Breitenbucher, J.G. / Gomez, L. / Botrous, I. / Marrone, T. / Barido, R. / Allerston, C.K. ...Dyck, B. / Branstetter, B. / Gharbaoui, T. / Hudson, A.R. / Breitenbucher, J.G. / Gomez, L. / Botrous, I. / Marrone, T. / Barido, R. / Allerston, C.K. / Cedervall, E.P. / Xu, R. / Sridhar, V. / Barker, R. / Aertgeerts, K. / Schmelzer, K. / Neul, D. / Lee, D. / Massari, M.E. / Andersen, C.B. / Sebring, K. / Zhou, X. / Petroski, R. / Limberis, J. / Augustin, M. / Chun, L.E. / Edwards, T.E. / Peters, M. / Tabatabaei, A. |
External links | J. Med. Chem. / PubMed:28406621 |
Methods | X-ray diffraction |
Resolution | 1.82 - 2.04 Å |
Structure data | PDB-5uoy: PDB-5up0: PDB-5uwf: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-8HM: ChemComp-HOH: ChemComp-8HP: ChemComp-8Q7: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / hydrolase / hydrolase inhibitor / HYDROLASE-HYDROLASE INHIBITOR complex / phosphodiesterase |