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TitleCergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines.
Journal, issue, pagesOncoimmunology, Vol. 6, Page e1277306-e1277306, Year 2017
Publish dateOct 21, 2016 (structure data deposition date)
AuthorsKlein, C. / Waldhauer, I. / Nicolini, V.G. / Freimoser-Grundschober, A. / Nayak, T. / Vugts, D.J. / Dunn, C. / Bolijn, M. / Benz, J. / Stihle, M. ...Klein, C. / Waldhauer, I. / Nicolini, V.G. / Freimoser-Grundschober, A. / Nayak, T. / Vugts, D.J. / Dunn, C. / Bolijn, M. / Benz, J. / Stihle, M. / Lang, S. / Roemmele, M. / Hofer, T. / van Puijenbroek, E. / Wittig, D. / Moser, S. / Ast, O. / Brunker, P. / Gorr, I.H. / Neumann, S. / de Vera Mudry, M.C. / Hinton, H. / Crameri, F. / Saro, J. / Evers, S. / Gerdes, C. / Bacac, M. / van Dongen, G. / Moessner, E. / Umana, P.
External linksOncoimmunology / PubMed:28405498
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-5m5e:
Crystal structure of a interleukin-2 variant in complex with interleukin-2 receptor
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-CYS:
CYSTEINE

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Interleukine-2 / interleukine-2 receptor / cytokine / interleukine-2 variant

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