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TitleDesign, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 27, Page 1955-1961, Year 2017
Publish dateFeb 13, 2017 (structure data deposition date)
AuthorsSabat, M. / Wang, H. / Scorah, N. / Lawson, J.D. / Atienza, J. / Kamran, R. / Hixon, M.S. / Dougan, D.R.
External linksBioorg. Med. Chem. Lett. / PubMed:28359790
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-5usq:
ALK-5 kinase inhibitor complex
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-8LY:
N-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2H-pyrazolo[4,3-b]pyridin-7-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / TGF-beta receptor type I / Serine/threonine-protein kinase receptor R4 / Activin receptor-like kinase 5 / Transferase-Transferase Inhibitor complex

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