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Structure paper

TitlePLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 3891-3896, Year 2017
Publish dateAug 29, 2016 (structure data deposition date)
AuthorsWu, R. / Sanishvili, R. / Belitsky, B.R. / Juncosa, J.I. / Le, H.V. / Lehrer, H.J. / Farley, M. / Silverman, R.B. / Petsko, G.A. / Ringe, D. / Liu, D.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28348215
MethodsX-ray diffraction
Resolution1.53 - 2.245 Å
Structure data

PDB-5t4j:
PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation
Method: X-RAY DIFFRACTION / Resolution: 2.231 Å

PDB-5t4k:
PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation
Method: X-RAY DIFFRACTION / Resolution: 2.245 Å

PDB-5t4l:
PLP and GABA Trigger GabR-Mediated Transcription Regulation in Bacillus subsidies via External Aldimine Formation
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

Chemicals

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-76U:
(4S)-5-fluoro-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid

ChemComp-77E:
(4R)-4-amino-6-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}hexanoic acid

Source
  • bacillus subtilis (bacteria)
  • escherichia coli (E. coli)
KeywordsTRANSCRIPTION REGULATOR / GabR / MocR / PLP / GABA / external aldimine / TRANSCRIPTION / TRANSFERASE

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