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Structure paper

TitleComputational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 8342-8355, Year 2017
Publish dateNov 3, 2016 (structure data deposition date)
AuthorsPalivec, V. / Viola, C.M. / Kozak, M. / Ganderton, T.R. / Krizkova, K. / Turkenburg, J.P. / Haluskova, P. / Zakova, L. / Jiracek, J. / Jungwirth, P. / Brzozowski, A.M.
External linksJ. Biol. Chem. / PubMed:28348075
MethodsX-ray diffraction
Resolution1.88 - 2.2 Å
Structure data

PDB-5mam:
Human insulin in complex with serotonin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-5mt3:
Human insulin in complex with serotonin and arginine
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

PDB-5mt9:
Human insulin in complex with serotonin and arginine
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-SRO:
SEROTONIN / neurotransmitter*YM

ChemComp-HOH:
WATER

ChemComp-ARG:
ARGININE

Source
  • homo sapiens (human)
KeywordsHORMONE / serotonin / complex / specificity / arginine

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