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Structure paper

TitleDiscovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 27, Page 2003-2009, Year 2017
Publish dateDec 21, 2016 (structure data deposition date)
AuthorsSun, Z. / Zhang, H. / Chen, Z. / Xie, Y. / Jiang, H. / Chen, L. / Ding, H. / Zhang, Y. / Zheng, M. / Luo, C.
External linksBioorg. Med. Chem. Lett. / PubMed:28347667
MethodsX-ray diffraction
Resolution1.724 Å
Structure data

PDB-5wuu:
Complex structure of the first bromodomain of BRD4 with an inhibitor that containing a 2H-chromen-2-one ring
Method: X-RAY DIFFRACTION / Resolution: 1.724 Å

Chemicals

ChemComp-7UU:
~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / BRD4 / inhibitor / complex

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