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Structure paper

TitleInhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Journal, issue, pagesNat Commun, Vol. 8, Page 14740-14740, Year 2017
Publish dateSep 8, 2016 (structure data deposition date)
AuthorsZhang, Z. / Obianyo, O. / Dall, E. / Du, Y. / Fu, H. / Liu, X. / Kang, S.S. / Song, M. / Yu, S.P. / Cabrele, C. ...Zhang, Z. / Obianyo, O. / Dall, E. / Du, Y. / Fu, H. / Liu, X. / Kang, S.S. / Song, M. / Yu, S.P. / Cabrele, C. / Schubert, M. / Li, X. / Wang, J.Z. / Brandstetter, H. / Ye, K.
External linksNat Commun / PubMed:28345579
MethodsX-ray diffraction
Resolution1.95 - 2.27 Å
Structure data

PDB-5lu8:
CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-5lu9:
Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-5lua:
Crystal structure of human legumain (AEP) in complex with compound 11b
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5lub:
Crystal structure of human legumain (AEP) in complex with compound 11
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EMC:
ETHYL MERCURY ION

ChemComp-5KN:
2,4-di(morpholin-4-yl)aniline

ChemComp-HOH:
WATER

ChemComp-3Y7:
7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / CYSTEINE PROTEASE / ALLOSTERIC INHIBITOR / ASPARAGINYL ENDOPEPTIDASE / ALZHEIMER'S DISEASE

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