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-Structure paper
Title | Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 8, Page 321-326, Year 2017 |
Publish date | Dec 2, 2016 (structure data deposition date) |
Authors | Metcalf, B. / Chuang, C. / Dufu, K. / Patel, M.P. / Silva-Garcia, A. / Johnson, C. / Lu, Q. / Partridge, J.R. / Patskovska, L. / Patskovsky, Y. ...Metcalf, B. / Chuang, C. / Dufu, K. / Patel, M.P. / Silva-Garcia, A. / Johnson, C. / Lu, Q. / Partridge, J.R. / Patskovska, L. / Patskovsky, Y. / Almo, S.C. / Jacobson, M.P. / Hua, L. / Xu, Q. / Gwaltney, S.L. / Yee, C. / Harris, J. / Morgan, B.P. / James, J. / Xu, D. / Hutchaleelaha, A. / Paulvannan, K. / Oksenberg, D. / Li, Z. |
External links | ACS Med Chem Lett / PubMed:28337324 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.05 Å |
Structure data | PDB-5u3i: PDB-5ufj: |
Chemicals | ChemComp-HEM: ChemComp-CMO: ChemComp-7SJ: ChemComp-HOH: ChemComp-86M: |
Source |
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Keywords | OXYGEN TRANSPORT / R2 QUATERNARY STATE |