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TitlePotent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 3750-3755, Year 2017
Publish dateOct 13, 2015 (structure data deposition date)
AuthorsChassagnon, I.R. / McCarthy, C.A. / Chin, Y.K. / Pineda, S.S. / Keramidas, A. / Mobli, M. / Pham, V. / De Silva, T.M. / Lynch, J.W. / Widdop, R.E. ...Chassagnon, I.R. / McCarthy, C.A. / Chin, Y.K. / Pineda, S.S. / Keramidas, A. / Mobli, M. / Pham, V. / De Silva, T.M. / Lynch, J.W. / Widdop, R.E. / Rash, L.D. / King, G.F.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28320941
MethodsNMR (solution)
Structure data

PDB-2n8f:
Chemical shift assignments and structure calculation of spider toxin pi-hexatoxin-Hi1a
Method: SOLUTION NMR

Source
  • hadronyche infensa (spider)
KeywordsTOXIN / Spider toxin / Inhibitor cystine knot / double knot toxin / ASIC1a antagonist / Ion channel modulator

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