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TitleCrystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity
Journal, issue, pagesACS Chem. Biol., Vol. 12, Page 1335-1345, Year 2017
Publish dateAug 17, 2016 (structure data deposition date)
AuthorsChen, C.-L. / Hsu, J.-C. / Lin, C.-W. / Wang, C.-H. / Tsai, M.-H. / Wu, C.-Y. / Wong, C.-H. / Ma, C.
External linksACS Chem. Biol. / PubMed:28318221
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-5gsq:
Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody Fc / homogeneous N-glycan / enhanced ADCC / di-sialylation

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