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Structure paper

TitleDiscovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 486, Page 620-625, Year 2017
Publish dateFeb 14, 2017 (structure data deposition date)
AuthorsSogabe, S. / Sakamoto, K. / Kamada, Y. / Kadotani, A. / Fukuda, Y. / Sakamoto, J.
External linksBiochem. Biophys. Res. Commun. / PubMed:28315327
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-5x54:
Crystal structure of the Keap1 Kelch domain in complex with a tetrapeptide
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • enterobacteria phage t7 (virus)
KeywordsTRANSCRIPTION/TRANSCRIPTION INHIBITOR / Transcription / Complex / Inhibitor / Kelch domain / NRF2 / Oxidative stress / TRANSCRIPTION-TRANSCRIPTION INHIBITOR complex

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