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TitleThe development of novel LTA4H modulators to selectively target LTB4 generation.
Journal, issue, pagesSci Rep, Vol. 7, Page 44449-44449, Year 2017
Publish dateFeb 9, 2017 (structure data deposition date)
AuthorsLow, C.M. / Akthar, S. / Patel, D.F. / Loser, S. / Wong, C.T. / Jackson, P.L. / Blalock, J.E. / Hare, S.A. / Lloyd, C.M. / Snelgrove, R.J.
External linksSci Rep / PubMed:28303931
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-5n3w:
Crystal structure of LTA4H bound to a selective inhibitor against LTB4 generation
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-YB:
YTTERBIUM (III) ION

ChemComp-IMD:
IMIDAZOLE

ChemComp-8KW:
3-[2-(2-hydroxyphenyl)ethyl]-5-methoxy-phenol

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Inflammation

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