Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha + Breast Cancer.
Journal, issue, pages	J. Med. Chem., Vol. 60, Page 2790-2818, Year 2017
Publish date	Sep 9, 2016 (structure data deposition date)
Authors	Burks, H.E. / Abrams, T. / Kirby, C.A. / Baird, J. / Fekete, A. / Hamann, L.G. / Kim, S. / Lombardo, F. / Loo, A. / Lubicka, D. ...Burks, H.E. / Abrams, T. / Kirby, C.A. / Baird, J. / Fekete, A. / Hamann, L.G. / Kim, S. / Lombardo, F. / Loo, A. / Lubicka, D. / Macchi, K. / McDonnell, D.P. / Mishina, Y. / Norris, J.D. / Nunez, J. / Saran, C. / Sun, Y. / Thomsen, N.M. / Wang, C. / Wang, J. / Peukert, S.
External links	J. Med. Chem. / PubMed:28296398
Methods	X-ray diffraction
Resolution	2.22 - 3 Å
Structure data	PDB-5t92: ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-{4-[(1R)-2-(4-fluorophenyl)-6-hydroxy-1-methy l-1,2,3,4- tetrahydroisoquinolin-1-yl]phenyl}prop-2-enoic acid Method: X-RAY DIFFRACTION / Resolution: 2.22 Å PDB-5t97: ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2 -yl)phenyl]-1,2,3,4- tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid Method: X-RAY DIFFRACTION / Resolution: 3 Å
Chemicals	ChemComp-77W: (2E)-3-{4-[(1R)-2-(4-fluorophenyl)-6-hydroxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]phenyl}prop-2-enoic acid ChemComp-HOH: WATER ChemComp-782: (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid
Source	homo sapiens (human)
Keywords	HORMONE RECEPTOR / NUCLEAR RECEPTOR / PROTEIN-LIGAND COMPLEX