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Structure paper

TitleRational Design of Protein C Activators.
Journal, issue, pagesSci Rep, Vol. 7, Page 44596-44596, Year 2017
Publish dateOct 16, 2016 (structure data deposition date)
AuthorsBarranco-Medina, S. / Murphy, M. / Pelc, L. / Chen, Z. / Di Cera, E. / Pozzi, N.
External linksSci Rep / PubMed:28294177
MethodsX-ray diffraction
Resolution2.34 Å
Structure data

PDB-5to3:
Crystal structure of thrombin mutant W215A/E217A fused to EGF456 of thrombomodulin via a 31-residue linker and bound to PPACK
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

Chemicals

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-K:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Autoactivation / THROMBIN-THROMBOMODULIN fusion protein

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