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-Structure paper
Title | Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 2038-2046, Year 2017 |
Publish date | Feb 1, 2017 (structure data deposition date) |
![]() | Schreier, J.D. / Embrey, M.W. / Raheem, I.T. / Barbe, G. / Campeau, L.C. / Dubost, D. / McCabe Dunn, J. / Grobler, J. / Hartingh, T.J. / Hazuda, D.J. ...Schreier, J.D. / Embrey, M.W. / Raheem, I.T. / Barbe, G. / Campeau, L.C. / Dubost, D. / McCabe Dunn, J. / Grobler, J. / Hartingh, T.J. / Hazuda, D.J. / Klein, D. / Miller, M.D. / Moore, K.P. / Nguyen, N. / Pajkovic, N. / Powell, D.A. / Rada, V. / Sanders, J.M. / Sisko, J. / Steele, T.G. / Wai, J. / Walji, A. / Xu, M. / Coleman, P.J. |
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Methods | X-ray diffraction |
Resolution | 2.61 - 2.85 Å |
Structure data | ![]() PDB-5uop: ![]() PDB-5uoq: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-GOL: ![]() ChemComp-MG: ![]() ChemComp-SO4: ![]() ChemComp-8G4: ![]() ChemComp-HOH: ![]() ChemComp-8G1: |
Source |
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![]() | TRANSFERASE/DNA/INHIBITOR / DNA INTEGRATION / VIRAL PROTEIN / RECOMBINATION-INHIBITOR-DNA COMPLEX / TRANSFERASE-DNA-INHIBITOR COMPLEX / TRANSFERASE-DNA COMPLEX |