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Structure paper

TitleStapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
Journal, issue, pagesACS Chem Neurosci, Vol. 8, Page 1313-1326, Year 2017
Publish dateMar 6, 2017 (structure data deposition date)
AuthorsFindeisen, F. / Campiglio, M. / Jo, H. / Abderemane-Ali, F. / Rumpf, C.H. / Pope, L. / Rossen, N.D. / Flucher, B.E. / DeGrado, W.F. / Minor, D.L.
External linksACS Chem Neurosci / PubMed:28278376
MethodsX-ray diffraction
Resolution1.7 - 2 Å
Structure data

PDB-5v2p:
CaV beta2a subunit: CaV1.2 AID-CAP complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5v2q:
CaV beta2a subunit: CaV1.2 AID-CEN complex
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-8VY:
1,3-bis(bromomethyl)benzene

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • rattus norvegicus (Norway rat)
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / ion channel / signaling / calcium

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