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TitleOvercoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.
Journal, issue, pagesAcs Infect Dis., Vol. 3, Page 502-511, Year 2017
Publish dateDec 15, 2020 (structure data deposition date)
AuthorsPapp-Wallace, K.M. / Becka, S.A. / Zeiser, E.T. / Ohuchi, N. / Mojica, M.F. / Gatta, J.A. / Falleni, M. / Tosi, D. / Borghi, E. / Winkler, M.L. ...Papp-Wallace, K.M. / Becka, S.A. / Zeiser, E.T. / Ohuchi, N. / Mojica, M.F. / Gatta, J.A. / Falleni, M. / Tosi, D. / Borghi, E. / Winkler, M.L. / Wilson, B.M. / LiPuma, J.J. / Nukaga, M. / Bonomo, R.A.
External linksAcs Infect Dis. / PubMed:28264560
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-7doo:
Crystal Structure of PenA beta-Lactamase-Avibactam Complex
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-NXL:
(2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide / antibiotic, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • burkholderia multivorans atcc 17616 (bacteria)
KeywordsHYDROLASE

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