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Structure paper

TitleThe crystal structure of Zika virus NS5 reveals conserved drug targets.
Journal, issue, pagesEMBO J., Vol. 36, Page 919-933, Year 2017
Publish dateJan 16, 2017 (structure data deposition date)
AuthorsDuan, W. / Song, H. / Wang, H. / Chai, Y. / Su, C. / Qi, J. / Shi, Y. / Gao, G.F.
External linksEMBO J. / PubMed:28254839
MethodsX-ray diffraction
Resolution1.804 - 2.6 Å
Structure data

PDB-5wz1:
Crystal structure of Zika virus NS5 methyltransferase bound to S-adenosyl-L-methionine
Method: X-RAY DIFFRACTION / Resolution: 2.507 Å

PDB-5wz2:
Crystal structure of Zika virus NS5 methyltransferase bound to SAM and RNA analogue (m7GpppA)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5wz3:
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP)
Method: X-RAY DIFFRACTION / Resolution: 1.804 Å

Chemicals

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-GTA:
P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

Source
  • zika virus (strain mr 766)
  • zika virus
KeywordsTRANSFERASE / zika virus / methyltransferase / MTase / SAM / methytransferase / RNA analogue / NS5 / RdRp / RNA-dependent RNA polymerase

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