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Structure paper

TitleNotch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Journal, issue, pagesScience, Vol. 355, Page 1320-1324, Year 2017
Publish dateJan 19, 2017 (structure data deposition date)
AuthorsLuca, V.C. / Kim, B.C. / Ge, C. / Kakuda, S. / Wu, D. / Roein-Peikar, M. / Haltiwanger, R.S. / Zhu, C. / Ha, T. / Garcia, K.C.
External linksScience / PubMed:28254785
MethodsX-ray diffraction
Resolution2.506 Å
Structure data

PDB-5uk5:
Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3)
Method: X-RAY DIFFRACTION / Resolution: 2.506 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsSIGNALING PROTEIN / Notch / Jagged / Delta / Glycoprotein

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