タイトル | Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase. |
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ジャーナル・号・ページ | Angew. Chem. Int. Ed. Engl., Vol. 56, Page 3833-3837, Year 2017 |
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掲載日 | 2016年4月17日 (構造データの登録日) |
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著者 | Fox, J.M. / Kang, K. / Sastry, M. / Sherman, W. / Sankaran, B. / Zwart, P.H. / Whitesides, G.M. |
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リンク | Angew. Chem. Int. Ed. Engl. / PubMed:28252841 |
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手法 | X線回折 |
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解像度 | 1.1 - 1.34 Å |
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構造データ | PDB-5jdv: Human carbonic anhydrase II (F131W) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.34 Å PDB-5je7: Human carbonic anhydrase II (F131Y) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-5jeg: Human carbonic anhydrase II (V121I) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.19 Å PDB-5jeh: Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.13 Å PDB-5jep: Human carbonic anhydrase II (T199S) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.19 Å PDB-5jes: Human carbonic anhydrase II (V121T) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.205 Å PDB-5jg3: Human carbonic anhydrase II (121T/N67Q) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.21 Å PDB-5jg5: Human carbonic anhydrase II (V121T/F131Y) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.19 Å PDB-5jgs: Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.11 Å PDB-5jgt: Human carbonic anhydrase II (F131Y/L198A) complexed with 1,3-thiazole-2-sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å |
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化合物 | |
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由来 | - homo sapiens (ヒト)
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キーワード | LYASE / Anhydrase / Mutant / Hydrophobic / water |
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