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TitleBiochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 6810-6820, Year 2017
Publish dateSep 29, 2016 (structure data deposition date)
AuthorsAppleby, T.C. / Greenstein, A.E. / Hung, M. / Liclican, A. / Velasquez, M. / Villasenor, A.G. / Wang, R. / Wong, M.H. / Liu, X. / Papalia, G.A. ...Appleby, T.C. / Greenstein, A.E. / Hung, M. / Liclican, A. / Velasquez, M. / Villasenor, A.G. / Wang, R. / Wong, M.H. / Liu, X. / Papalia, G.A. / Schultz, B.E. / Sakowicz, R. / Smith, V. / Kwon, H.J.
External linksJ. Biol. Chem. / PubMed:28235803
MethodsX-ray diffraction
Resolution1.7 - 2.999 Å
Structure data

PDB-5th6:
Structure determination of a potent, selective antibody inhibitor of human MMP9 (apo MMP9)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5th9:
Structure determination of a potent, selective antibody inhibitor of human MMP9 (GS-5745 bound to MMP-9)
Method: X-RAY DIFFRACTION / Resolution: 2.999 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NCO:
COBALT HEXAMMINE(III)

Source
  • homo sapiens (human)
  • oryctolagus cuniculus (rabbit)
Keywordshydrolase/hydrolase inhibitor / metalloproteinase-9 antibody inhibitor / hydrolase-hydrolase inhibitor complex

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